Hi, Welcome to JustAnswer. I'm a licensed veterinarian and I'll be happy to help. Thanks for your question about Lily. If Lily had a full OVH (and most dogs receive this with the ovaries and major part of the uterus removed), then she would not be producing any of the female hormones such as estrogen and progesterone. . .unless there is an ovarian remanent or even extraneous ovarian tissue along the ovarXXXXX XXXXXgament. Has Lily had and vaginal discharge or swelling? She would most likely respond in these ways if she has circulating female hormones still.
Otherwise, I'd be concerned that Lily is sick and not feeling well with some other disease or problem. Does Lily have any other symptoms other than grumpiness?
Thanks for your reply. Is Lily also itchy. . .scratching and licking excessively? Does she seem to have normal energy? Is she drinking a normal amount of water and producing a normal amount of urine?
I think that is the best plan for her. I also recommend a urinalysis because this is the only way that lower urinary tract disease can be found, and bladder infections are fairly common.
One other thing you can look at is her vulva. Any swelling or scant bloody discharge? As I mentioned above, if there are any ovarian remnants or aberrant ovarian tissue in her, then she could be having female hormone swings. . .this is unlikely, but just something to keep in mind.
Good luck! I'll put you in for a follow up in about 2 weeks, as I'd like to hear how things are going for you and how she is doing.