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Hello I am Dr. Joey. Thanks for trusting me to help you and your pet today. I am a licensed veterinarian with over 15 years of experience. I look forward to working with you.
No, arthritis should not be a side effect of any of the medications that you are currently administering to her. Polyarthritis is very concerning. THis may not be related at all to the PSS, but instead be immune-mediated or rhumatoid arthritis. I assume radiographs (xrays were taken) and your vet may have spoken about doing a joint tap to sample what is going on there (that helps us rule out that it is a bacterial arthritis). There is a clear difference on xrays between immune-mediated and rhumatoid arthritis. You can also do a blood test for a rhumatoid factor to know if this is what is going on. If you have immune-mediated or rhumatoid arthritis then it will require different medications to treat or at least help
I'm sorry, it looks like she may not have portosystemic shunt (PSS) but regular liver disease; regardless her condition is potentially unrelated to the arthritis. It would be nice to link them.
I see xrays were not taken. They actually could be very useful, but if you elected not to do this, then as a minimum I would discuss doing a rhumatoid factor (blood test) with your vet to perhaps get an idea if rhumatoid arthritis needs to be considered. This is a progressive and painful process that does not carry a very good prognosis.
Overall she is a very complicated patient. It sounds like her liver disease is controlled, but we do not know for how long we may have control of this if you are to a point of already using two diuretics to control the ascites. I would probably agree that conservative management is probably the way to go, but I would pursue the arthritis a bit further. she is too young to have age-related arthritis. This is probably an immune system problem. That is going to require a drug other than pain relief to help such as prednisone.
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