Many thanks for you long comprehensive reply. I really do not think I can take it all in as it is obviously a complicated set of remedies.
We apply every 28 days Advocate Spot on 400 for the flea and parasite control purchased on line from DiscountPetCare.com, although supplied in the correct packaging is it possible this could be substandard?
I again inspected his skin last night and there was 1 red mark on his back which I cannot find again today. Early this morning when he got out of bed his top rear back was wet from licking so I gave him a Piriton tablet and he has calmed down now. Perhaps a month ago the vet did say to give him Piriton and after 10 days with no response we stopped.
I think I will make another appointment with the vet and show him your report and take it from there.
Many thanks and I may contact you again.