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Dr. SH
Dr. SH, Physician
Category: Endocrinology
Satisfied Customers: 8781
Experience:  Doctor of Medicine
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Please can you give me studies of contra indicated use of Metformine

Customer Question

Please can you give me studies of contra indicated use of Metformine 500mg with 300mg Clozapine. The team say this is for weight loss but she has not lost weight.
Submitted: 4 years ago.
Category: Endocrinology
Expert:  Dr. SH replied 4 years ago.

Dr. Shahzad MD :

Hi there

Dr. Shahzad MD :

Thank you for writing to us.

Dr. Shahzad MD :

I am Dr. Shahzad and will be helping you out with your queries.

Dr. Shahzad MD :

The only interaction between clozapine and metformin is that atypical antipsychotics like clozapine have been associated with raised blood glucose levels which may alter blood glucose control in people suffering from diabetes.

Dr. Shahzad MD :

If a person who is on this combination of medications is not a diabetic then this combination can be safely used.

Dr. Shahzad MD :

Here is an interaction checker that medical professionals commonly use.

Dr. Shahzad MD :

http://reference.medscape.com/drug-interactionchecker
Enter both these drugs one by one in this interaction checker in the weblink and you will get the interaction.

Dr. Shahzad MD :

Metformin is a medication that is very commonly used in patients of Type 2 diabetes for glucose control.

Dr. Shahzad MD :

It may also be used in ladies with polycystic ovary disease.

Dr. Shahzad MD :

It may lead to weight loss in some but not all people using this.

Dr. Shahzad MD :

Clozapine causes weight gain and high blood glucose levels which is why metformin is sometimes given in combination with clozapine to combat these side effects of clozapine.

Dr. Shahzad MD :

So even if she is not gaining weight and her glucose levels are normal while on this combination even this is a good thing.

Dr. Shahzad MD :

Let me know if you have any further questions.

Dr. Shahzad MD :

This session is open till you are satisfied.

Dr. Shahzad MD :

Kindest Regards