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Thank you for your prompt reply.
I'm not clear about the last sentence..... she may leave the UK and come back anytime provided she has not been out of the UK for 2 years or more!
She has travelled to Pakistan twice since entering the UK in May 2012, but each time for less than 90 days.
She intends to visit Pakistan again for less than 90 days but I wasnt sure if she can go, as her ILE stamped on visa was May 2014