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I have no history of head trauma.
I asked about anafranil because of the following paper:
Intracranial haemorrhage and the use of selective serotonin reuptake inhibitors, Br.J.Clin.Pharmacol.2000 50(1) 43-47
I realise is a tricyclic antidepressant but still involves the serotonin pathway.
In the absence of an alternative explanation, its a bit too much of a co-incidence.
Trials of Anafranil lasted 10 weeks before the FDA approved it with the proviso that there was no long-term safety data and physicians should act accordingly!
Apologies for not replying earlier - this email address has been out of use.
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Problem is, no-one knows what these psycho-active drugs are doing to the brain, and a meta-analyses of clinical trials, mostly run by the pharmaceutical companies who stood to gain financially, showed that anti-depressants worked little better than placebos at alleviating depression, and not in terms of rebalancing chemical imbalances in the brain!
The chemical imbalance theory has been shown to be a myth, but, nevertheless has been cleverly marketed by the pharmaceutical companies to the advantage of their shareholders.
You haven't answered my question:
Have there been trials on the safety of long term use of Anafranil?
If so, where were they published?