Hello. I'm Dr. Phil, licensed and practicing internist. Excellent service is my goal.
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This is Dr. DavidI am a cancer doctorwe are starting to offer xofigo to patients who have hormone refractory prostate cancer whos cancer continue to grow dispite anti-testosterone therapy. I disagree with the other expert. the side effects are minimal to noneblood counts stay good. the risks for drops in blood counts in the xofigo group was less than the placebo group. LESS than placebo! patients have less pain and better quality of life on their questionnaires on xofigo.much better tolerated and much less side effects than taxotere chemotherapy and less expensive than Provenge.
here is the NEJM trial
"A significantly higher percentage of patients who received radium-223, as compared with those who received placebo, had a meaningful improvement in the quality of life according to the FACT-P total score (i.e., an increase in the score of ≥10 points on a scale of 0 to 156, with higher scores indicating a better overall quality of life) during the period of study-drug administration (25% vs. 16%, P=0.02). The mean change in the FACT-P total score from baseline to week 16 significantly favored the radium-223 group, as compared with the placebo group (−2.7 vs. −6.8, P=0.006)."
Xofigo can also be used with second generation antiandrogens such as Xtandi and Zytiga.
I prefer Zytiga's mechanism of action.
Thank you, XXXXX XXXXX for your remarks. Radium 223 is a very expensive treatment and before we could even consider it we need to know its success rate. Also, as we live in Ireland I was wondering if the treatment is carried out anywhere here rather than travelling to London for it.
Dr David, apart from the lack of side effects is 'Xofigo' effective in prolonging life?