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According to the Centers for Disease Control and Prevention (CDC), patients with known penicillin allergies should undergo penicillin allergy skin testing and penicillin desensitization, if necessary.
The 2010 CDC STD treatment guidelines recommend desensitization in penicillin-allergic pregnant women, followed by treatment with penicillin.
Doxycycline is used as alternative therapy for syphilis infection.
Initial therapy: 200 mg/day divided twice daily for the first 24 hours which may either be given orally or intravenously. THEN
Maintenance: 100-200 mg/day
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Unsure about the dosage on first day - is it 200mg in one go or divided into parts? Then you say between 100-200mg maintenance, but for how many days should this continue? 40Yr Male in good general health.
100 mg 12 hourly in the first 24 hours i.e. two doses of 100 mg twelve hours apart. Then you should take 100 mg once daily or 100 mg twice daily depending on the severity of infection for 28 days.
Would you recommend the single 2g dose of azithromycin?
Can Doxycycline be taken simply as 2 x 100mg for 14 days with the same outcome? What are the dangers of leaving secondary syphilis untreated for a few weeks once classic signs (rash on palms of hands and feet) begin to appear?
Being in a foreign country with a few weeks remaining before returning back to Europe (and then be treated) was the background to my question as to 'what are the consequences of leaving (suspected) secondary syphilis untreated for a few weeks'? My understanding is that tertiary syphilis develops some time after secondary?