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Hello, this is Dr K.. Answers are not medical advice and do not constitute a doctor/patient relationship. I look forward to helping you today.
How old is your wife?
If the tests were negative, shes not pregnant.
She may feel her breasts are fuller since this is the time before her period
When this happens, premenstrual symptoms such as breast swelling may be worse
You cannot really do anything but wait for a period :)