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Dr. Phil, MD
Dr. Phil, MD, Board Certified Physician
Category: Medical
Satisfied Customers: 53143
Experience:  GP in the United States
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After first session of oxyplatin chemotherapy my fathers ALP

Customer Question

After first session of oxyplatin chemotherapy my fathers ALP level
Has jumped from 75 to 225. What could be the reason ?
He has metastic colorectal cancer with liver mets
Submitted: 1 year ago.
Category: Medical
Expert:  Dr. Phil, MD replied 1 year ago.
still need help?
Customer: replied 1 year ago.

Yes please

Expert:  Dr. Phil, MD replied 1 year ago.
Thanks for this question. This could be related to progression/non response of the cancer. It could simply be toxicity from the chemo as well. What is his CEA level trend?
Customer: replied 1 year ago.

Well it was 65 just before start of chemo . The chemo is ixy

Expert:  Dr. Phil, MD replied 1 year ago.
we will need to trend the CEA to see if he is responding.
Customer: replied 1 year ago.

It was 60 beofre chemo and after the first infussion it jumped to 80.

so was a rise within 3 weeks . Surely it should have reduced right ?

also does metastic colon cancer respond tI chemo

or v few ppl do ?

Expert:  Dr. Phil, MD replied 1 year ago.
That is correct. The rise in CEA could be due to inflammation during treatment as well. You need to check it after chemo is done
Customer: replied 1 year ago.

Yes I suppose your right . But is the ALP rise not too much from 75 to 225? Could that b liver failure ?

Expert:  Dr. Phil, MD replied 1 year ago.
No that is not liver failure. The number would be much higher
Customer: replied 1 year ago.

Ok that's a relief then . Are 8 mets in the liver alot ? One is 10 cm

Expert:  Dr. Phil, MD replied 1 year ago.
Yes, that is a lot. I'm sorry
Expert:  Dr. Phil, MD replied 1 year ago.
Yes, that is a lot. I'm sorry
Customer: replied 1 year ago.

Are a lot of ppl generally resistant to chemotherapy ?

Expert:  Dr. Phil, MD replied 1 year ago.
No, not really. Most respond quite well.
Dr. Phil, MD, Board Certified Physician
Category: Medical
Satisfied Customers: 53143
Experience: GP in the United States
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Expert:  Dr. Phil, MD replied 1 year ago.
I appreciate the excellent rating.

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