Hi. We can continue after this but no, not having a colon would not impact the absorption of tablets.
That said, it's possible that you don't have enough acid production in your stomach. Some medications like PPI's--Nexium, for example--cause that but if you aren't on a medication like that you should have a gastric pH study. If that's the problem it could be from a vitamin B12 deficiency or a lack of sufficient pancreatic digestive enzymes, and in those cases, B12 injections or oral pancreatic enzymes would treat that
I am not on medication like that, my reason for asking is that because I am on Effexor for Depression, and the tables were not effective until I reached a dose of 375mg. I am also on the XR version of the tablets, and I was always curious if XR and absorption was impacted by my lack of colon. Would taking B12 or Digestive enzymes help improve absorption even without knowing my pH?