Hi I may need a forensic pathologist to answer my questions. I am involved in research and would like to know that when a deceased patient is found to have 8 mg per cent of chloral hydrate in their blood and 13 mg per cent of pentobarbital in their liver, could this have been administered via the rectal (enema) route or via oral or via both routes? Could you tell me that if the bottom part of the sigmoid colon was found to have a distinct colour purple during the autopsy could this mean that the lethal overdose of pentobarbital entered the body via the rectal route and this could be the tissues reaction to the massive overdose of alkali substance of the drug? During an autopsy there were tissue samples taken from the intestines, stomach, urine, blood, liver and kidneys that the medical examiner wanted to examine. Would the examination from these samples tell where the drugs entered the body? If the route of entry was orally taken and the stomach was empty apart from 20cc of a brownish mucoid fluid, then how come the liver is 13 mg percent of pentobarbital and 8 mg per cent of chloral hydrate in their blood? The deceased would not have lived long enough to have that amount in their body via the oral route. Is this correct? So therefore this must have been administered via the rectal route. If they were injected then they would definitely not lived long enough for these results to occur as death would have occurred within minutes. As in your last answer you stated that the concentration of the drug will vary in different parts of the body. I know that drugs via the rectal route will be far quicker to absorb into the blood than that of the oral route. So when a person is administered a massive overdose via the rectal route would they expel some of the substance when their body can no long sustain such a lethal dose when they become unconscious or will their body absorb all the lethal dose (is this how the liver and the blood was so high?) Could you also tell me in which organs would the drugs be distributed caused by the lethal overdose via the rectal (enema) route and which organs would the drugs be distributed via the oral route. I do hope you will be able to assist me on answering the above questions. Thank you. Sincerely KarenXXX
Hi I definitely need the questions answered.
Mrs Karen XXX
Hello Dr Love, I am very pleased with your reply. Like I said I am involved in research it is for a book that I am writing.
I used to be a Company Director of a medical company called Altomed Ltd and I was bought out in February last year as I got divorced and my ex is still there, he is also a director. I have always been interested in research as I did quite a lot in the business I was in. I am now writing and doing a lot of research on the subject of the mysterious death of Marilyn Monroe. I have always been interested in her life and death, and visited the USA twice this year in connection with the research I am doing. I would like to ask you if I could use your name (Dr D Love) and information that you gave me? It's quite hard writing without proof or evidence, in fact it is impossible.
Mrs K L Myers
Thank you, ***** ***** appreciated.
Could you also tell me in which organs would the drugs be distributed or targeted caused by the lethal overdose via the rectal (enema) route? I know that the administration of drugs will allow the drug to be absorbed directly into the bloodstream and neutralizes the body’s ability to reject the toxin by vomiting, but where will the drugs then target?
Hi doctor I am sorry I sent the wrong question, here is what I was suppose to send you. I am not a medical qualified person so I hope you can bear with me.
I can appreciate your answers, and fully understand it. I know that the administration of drugs via the rectal route will allow the drug to be absorbed directly into the bloodstream and neutralizes the body’s ability to reject the toxin by vomiting, will it be impossible once it reaches the blood stream to save someone's life (is this correct)?
I know that the medical examiner in this case collected tissue samples from the intestines, stomach and contents, urine, blood, liver and kidneys to be tested for further toxicology investigation. Only the liver and the blood was tested the other tissue samples were discarded! Would these 'discarded' tissue sample have told where the drugs entered the body, because once the persons circulatory system stops they do not absorb the drug into their system any further and the remaining unabsorbed drug will stay behind in the route it entered the body (ie. in the stomach when orally taken and in the large intestine when administered via rectally) is this correct?
I was also under the impression that the person who was administered the dose orally would not have lived long enough to have such a high dosage in the liver and in the blood (is this correct)?
It was also found that the sigmoid colon was found to have a very purplish discoloration. I have also found out through extensive research that you can get the small bulb type enema with no bag, no hose. The nozzle is inserted into the rectum and the bulb, filled with the medicated solution, is then squeezed, forcing the solution up into the colon. The solution would naturally jettison upward until it hit the wall of the colon lining when the colon turns to enter the lower intestine, it is exactly at this point that the purplish discoloration occurs in Marilyn’s body. The question is if Marilyn wanted to commit suicide why overdose via enema?
Could this be the tissues reaction to the massive alkali substance of the drug that was administered.?
With great appreciation,
Hi Dr Love you stated in your last answer below:-
As for the new questions - will it be impossible once it reaches the blood stream to save someone's life (is this correct)? This is not correct. For most drugs, treatment is by supportive care, such as the current ordeal involving Lamar Odom, although there are specific drugs for which there are antidotes.
I would like to ask if there would have been antidotes back in August 1962?
One more question as its getting late. If this lethal toxic dose was given it was obviously meant to kill Marilyn. With the amount that was found in the (8mg %) in blood and (13mg %) in the liver. How long would she have lived after she had been administered this amount? Or give a good guess?