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Dr. David
Dr. David, Doctor (MD)
Category: Oncology
Satisfied Customers: 46955
Experience:  Board Certified Oncologist
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is there a treatment for Thyroid anaplastic cancer?

Resolved Question:

is there a treatment for Thyroid anaplastic cancer?
Submitted: 3 years ago.
Category: Oncology
Expert:  Dr. SH replied 3 years ago.

Dr. Shahzad MD :

Hi there. Thank you for your question. I will be helping you out with your queries

Dr. Shahzad MD :

I am really sorry to learn about your wife.

Dr. Shahzad MD :

Unfortunately anaplastic cancer is the most aggressive of all the thyroid cancers.

Customer:

so, no treatment available? something like monoclonal antibody treatment?

Dr. Shahzad MD :

Anaplastic thyroid cancer is highly unlikely to be curable either by surgery or by any other treatment modality

Dr. Shahzad MD :

Radiation therapy usually combined with chemotherapy. No role of monoclonals.

Dr. Shahzad MD :

Sorry

Dr. Shahzad MD :

There is a role for monoclonal antibodies but that is in investigational phase and not proven effective as yet.

Dr. Shahzad MD :

These include new drugs, such as fosbretabulin (a type of combretastatin), bortezomib and TNF-Related Apoptosis Induced Ligand (TRAIL),

Customer:

Do radiation combined with chemotherapy would be a solution or just a palliative treatment?

Dr. Shahzad MD :

Usually only a palliative treatment.

Dr. Shahzad MD :

In your wife's case its most likely to be palliative since it has spread to the trachea and the oesophagus.

Dr. Shahzad MD :

are you with me?

Customer:

Right, so ... those new drugs you mentioned, they're also ineffective?

Dr. Shahzad MD :

They are in trial phase

Dr. Shahzad MD :

So we do not know for sure.

Customer:

How does one participate in the trials?

Dr. Shahzad MD :

You would have to ask the hospital in your area if there is any trial going on there.

Dr. Shahzad MD :

http://thyroid.about.com/b/2009/05/28/anaplastic-thyroid-cancer-trial-fosbretabulin.htm

Dr. Shahzad MD :

Here is a website which you can refer to for possibly placing her on a drug trial

Dr. Shahzad MD :

http://www.cancer.gov/clinicaltrials/search/view?cdrid=647587&version=HealthProfessional

Dr. Shahzad MD :

Here is another web link.

Dr. Shahzad MD :

Are you with me?

Dr. Shahzad MD :

http://www.medscape.com/viewarticle/736007_4

Dr. Shahzad MD :

this link gives you a detail on the trials that have been done and the results

Dr. Shahzad MD :

This session is open to your questions until you are satisfied.

Expert:  Dr. David replied 3 years ago.
This is Dr. David

I am a cancer doctor

just because there are no approved drugs for anaplastic thyroid cancer doesn't mean there are no options for targeted therapy.

there are drugs approved for medullary thryoid carcinoma and often times these are often used for anaplastic thyroid cancers which are metastatic.

agents such as Combretastatin, and Vandetanib, and Cabozantinib may help slow down the growth of the cancer.

also radioactive I-131 high dose iodine can still play a part if the cancer is uptaking iodine

and clinical trials in australia for metastatic thyroid cancers are enrolling patients as well

you can search for clinical trails here in australia

http://www.australiancancertrials.gov.au/search-clinical-trials/advanced-search.aspx

let me know if you have other questions.
Dr. David, Doctor (MD)
Category: Oncology
Satisfied Customers: 46955
Experience: Board Certified Oncologist
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