Hello Dr Salkin. Thank you for getting in touch so quickly.
This all started when Eric collapsed at home. I took him to the vets and an ultrasound scan showed that his spleen had ruptured and he was losing blood. Surgery to remove the spleen was performed within 2 hours, and a large tumour (7 - 8cm wide) was found to have ruptured. At this stage, samples were sent off for biopsy immediately. This was of the splenic tumour only. My vet cleared the abdomen of blood, but samples of surrounding organs were not biopsied as X-rays and the Ultrasound scans had not shown any other abnormalities.
After recovery from surgery, he was pretty much back to normal, and placed on a regimen of vincristine once a week for a month together with
Prednisolone initially (40mg) a day, followed by vincristine once a month. After the second chemo treatment, he developed quite severe diarrhea, and the vet recommended that he miss the next treatment. But the diarrhea continued, and we were told that it was probably the steroid causing the problem. This was cut down to its present level (5mg per day) when bowel movements became normal again.
He has been normal in himself since and is due to begin chemo again tomorrow. I started noticing the weakness about a week ago and because when you have an unwell animal, you tend to be on the lookout all the time for the smallest symptoms. On his walks however, he runs around happily with our other dog, and rarely seems unsteady. It seems to show itself more after he has been sleeping, mainly in the evenings. I hope this helps you get a clearer picture. When he goes to the vets, he is examined for lymph node enlargement, which so far has not been evident. He seems well in every other way and is eating well.
Many thanks - XXXXX XXXXX