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Please get in touch with the Solicitors Regulation Authority to see if they have details of whom your uncle's solicitor sold his business to as the deeds may possibly with the whoever acquired the business.
The SRA website is here: https://www.sra.org.uk/home/home.page
If the property is registered, the land registry will have an electronic record of the deeds and the original deeds are strictly not required, see here: https://hmlandregistry.blog.gov.uk/2018/02/19/title-deeds/
You may also consider taking out indemnity insurance for lost title deeds e.g https://www.lawsureinsurance.co.uk/our-products/title-protection/lost-title-deeds/
Hope this helps. If so, please leave a positive rating.
Yes, I am aware.
My reference to business is the solicitor's business.