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Dr. Phil, MD
Dr. Phil, MD, Board Certified Physician
Category: Medical
Satisfied Customers: 58373
Experience:  GP in the United States
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After first session of oxyplatin chemotherapy my fathers ALP

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After first session of oxyplatin chemotherapy my fathers ALP level
Has jumped from 75 to 225. What could be the reason ?
He has metastic colorectal cancer with liver mets
still need help?
Customer: replied 2 years ago.

Yes please

Thanks for this question. This could be related to progression/non response of the cancer. It could simply be toxicity from the chemo as well. What is his CEA level trend?
Customer: replied 2 years ago.

Well it was 65 just before start of chemo . The chemo is ixy

we will need to trend the CEA to see if he is responding.
Customer: replied 2 years ago.

It was 60 beofre chemo and after the first infussion it jumped to 80.

so was a rise within 3 weeks . Surely it should have reduced right ?

also does metastic colon cancer respond tI chemo

or v few ppl do ?

That is correct. The rise in CEA could be due to inflammation during treatment as well. You need to check it after chemo is done
Customer: replied 2 years ago.

Yes I suppose your right . But is the ALP rise not too much from 75 to 225? Could that b liver failure ?

No that is not liver failure. The number would be much higher
Customer: replied 2 years ago.

Ok that's a relief then . Are 8 mets in the liver alot ? One is 10 cm

Yes, that is a lot. I'm sorry
Yes, that is a lot. I'm sorry
Customer: replied 2 years ago.

Are a lot of ppl generally resistant to chemotherapy ?

No, not really. Most respond quite well.
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