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Dr. David
Dr. David, Board Certified MD
Category: Medical
Satisfied Customers: 49169
Experience:  Board Certified Physician
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I have been taking irbesartan and indapamide 150 years and

Customer Question

Good afternoon Doctor
I have been taking irbesartan and indapamide 150 for many years and have more recently been presrcibed duloxetine for lower back pain which i've had for nearly three years. I began duloxetine 30mg for 28 days and then 40mg one daily starting June 28th. I have had some minor side effects from day one but seemed to be tolerating it fairly well until this morning when I rose and went to the kitchen. the room began to move and i had to grip the work surface to avoid falling.I sat down and began to settle but had no appetite but needed to take on something to help with my daily medication and chose a vegetable soup.
No sooner had I eaten I began vomiting violently and my balance and coordination was all over the place. I was sweating profusely but managed to get to my bed and slept 4.5 hour from 7:30 til mid-day. I've managed to keep down one weetabix and a couple of glasses of water but when I stand i become dizzy and unsteady. Should I stop the duloxitine or reduce intake to one every two days or are the two events unrelated. My wife is just fine. Thank you and my apologies for bothering you.
Kind regards ***** ***** 28.02.1942 patient Old School Surgery Seaford East Sussex Dr S Palit
Submitted: 1 year ago.
Category: Medical
Expert:  Dr. David replied 1 year ago.

This is Dr. David

duloxetine and indapamine combination can increase risks for low sodium levels in your blood and SIADH syndrome of inappropriate antidiuretic hormone levels which can can cause you to retain fluid and drop your sodium levels.

I would not stop your duloxetine right away. this medications needs to be slowly tapered down to stop

I would see a doctor right away and get blood testing and blood pressure testing

you may need to have your indapamine changed to another blood pressure medication which does not interact with duloxetine.

let me know if you have other questions.

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