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Dr. SH
Dr. SH, Board Certified Physician
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Experience:  Doctor of Medicine
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What is the test for Connective tissue diseases?

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What is the test for Connective tissue diseases?

Connective tissue diseases are autoimmune diseases such as lupus.

Customer: replied 1 year ago.
What are the tests for Autoimmune Glomerular Nephritis, Panarteritis Nodosa, Graves Disease, Lichen Planus.

Polyarteritis nodosa:

  • Elevated erythrocyte sedimentation rate (ESR) and/or C-reactive protein -

  • Leukocytosis, normochromic anemia, or thrombocytosis

  • Hepatitis B surface antigen and hepatitic C serologies

  • Elevated creatinine level

  • Mild proteinuria

  • Elevated levels of liver enzymes

  • Hypergammaglobulinemia - Found in 30% of patients with PAN

Autoimmune Glomerular Nephritis,

  • Complete blood cell count (CBC) with differential

  • Serum electrolytes, BUN, creatinine, lactate dehydrogenase (LDH), creatine phosphokinase (CPK), and liver function tests: The most common abnormality is an increased serum creatinine level. However, the level can be normal at presentation. Tissue enzyme (ie, LDH, CPK) levels may be elevated if the amount of inflammation is significant enough to result in myalgias.

  • Urinalysis with microscopy: Proteinuria is almost always present but is rarely greater than 2-3 g in 24 hours. Microscopic hematuria is invariably present and may be the only clue to renal disease at presentation. The presence of red cell casts indicates glomerular inflammation and is a very helpful clue.

  • Erythrocyte sedimentation rate: Although a nonspecific finding, the rate is usually elevated with active disease.

  • C-reactive protein: levels are elevated and correspond with disease activity.

  • Antinuclear antibody (ANA) titer

  • ANCA with ELISA subtyping

  • Cryoglobulins

  • Hepatitis profile

  • Urine and serum protein electrophoresis

Graves Disease

  • Antibody test for thyroid disease
  • Thyroid hormone testing

Lichen planus is generally a clinical diagnosis and no tests are usually required but a skin biopsy may be done in case there is doubt.

Direct immunofluorescence study in lichen planus (LP) reveals globular deposits of immunoglobulin M (IgM) and complement mixed with apoptotic keratinocytes.

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