This is Dr. David
I am sorry about your wife.
waking up disoriented is a serious issue.
this is called a mental status change and needs to be evaluated by a GP doctor or neurologist right away.
she needs blood work and a scan of her brain to find out what is going on and causing her behavioral changes.
it could be many potential issues, metabolic issues, reaction to her pain medications, mass in the brain, infection, or something else.
she needs to be checked for urinary tract infection.
she needs blood testing
and a scan of the brain with CT scan or MRI scan.
and she needs to have her medications reviewed.
lyrica and cymbalta or savalla can help with fibromyalgia pains. is she on these?
you can also take her to the hospital A&E department if she is having mental status changes and ask them for testing and workup as well as this is an urgent matter.
let me know if you have questions.