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Dr. D. Love
Dr. D. Love, Doctor
Category: Medical
Satisfied Customers: 20887
Experience:  Family Physician for 10 years; Hospital Medical Director for 10 years.
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I’m currently suffering with depression (not severely) but

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Hi there, I’m currently suffering with depression (not severely) but my husband is and it’s had an adverse affect on our marriage and family life. I am on methotrexate for psoriasis and would like to try some herbal “antidepressants”. I know that I cannot take St. John’s wort with methotrexate, but wondered if it is safe to take 5HTP ? I have researched online and the only interactions I can find is with other antidepressants or antidepressant type supplements. I take nothing other than methotrexate and folic acid. Would 5 HTP be safe to take? Thank you.
Assistant: How long have you been feeling this way? Have you reached out to anyone about this yet?
Customer: Lots of people and because my husband has been suffering for a long time it has knocked me quite hard. On the Becks?? Scale for depression I come out as borderline clinical depression but this week my husband has walked out and I just would like something gentle to take that would help me cope until we can get him some help. He is seeing a dr today.
Assistant: Anything else in your medical history you think the doctor should know?
Customer: No nothing at all . Just want to make sure 5HTP is safe with methotrexate. I believe it is but would like to double check.

Hello from JustAnswer. This is Dr. Love.

Yes, it is safe to take 5-HTP with methotrexate. There are no reported adverse interactions between methotrexate and 5-HTP. And the physiology of 5-HTP would not be expected to interact with methotrexate.

If i can provide any clarification, please let me know.

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