Unilateral lower extremity edema below the knee commonly results from deep venous thrombosis, venous insufficiency, or lymphedema. The patient history, a physical examination, and lower extremity venous duplex ultrasound often reveal the underlying etiology, which is frequently of vascular origin.
Lipedema is a disease characterized by subcutaneous adipose tissue deposition, and though rare, it can be the other cause of your swelling.
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