This is the latest 2019 review;
The cross-references are in the brackets.
Strongly associated with the probability of malignancy, nodule size represents a cornerstone in nodule assessment in all recommended algorithms.[1,2,3,4] Based on observations in high-risk patients from lung cancer screening trials,[10,84] a cut diameter below 6 mm is proposed by most recent guidelines as an indicator of acceptably low cancer risk (<1%).[1,4] The same cutoff applies for both solitary and multiple solid nodules as well as for solitary subsolid nodules.[1,4] A second clinically relevant cutoff diameter is >8 mm. Using data from the NELSON trial, a high lung cancer probability of 9.7% can be estimated for solid nodules ≥8 mm compared to an intermediate probability of about 1% in those smaller than 8 mm (and larger than 5 mm).[2,84]
This is the latest guideline;
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