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If you have been on sertraline for some time then you can continue it with sudafed.
There is no serious interaction, however, palpitation and insomnia may sometimes be experienced. Best wishes,Please reply back if you need any further clarification.It was my pleasure to help you today.If I have answered all your questions, Please rate my response Excellent (click on the 5th star on top).
caffeine and phenylephrine both are stimulant in nature.
occasional or as needed use may be ok for headaches or sinus congestion.
Long term regular use is discouraged.