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If the patient has known airway infection with Pseudomonas that is resistant to oral quinolones, the initial antibiotic choice is based on the sensitivity profile from culture data and history of allergy to antibiotics.
There are many options depending upon the clinical need:
Novel beta-lactam-beta-lactamase inhibitor combinations:
Novel carbapenem-beta-lactamase combination:
•Dosing of polymyxin B and colistin