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Dr. Bob
Dr. Bob, Neurologist (MD)
Category: Neurology
Satisfied Customers: 5657
Experience:  Neurology & Int Medicine (US Trained): 20 yrs experience
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I have found that if I take the smallest amount of alcohol

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I have found that if I take the smallest amount of alcohol while on medications such as low dose quetiapine for sleep I get a slight allergic swelling of the face. I have not seen any warning about this - are you familiar with it? Is there any way that I can get rid of the symptoms. Is there any way I can continue to take quetiapine, for example by taking an antihistamine before the quetiapine? .
Customer: replied 1 year ago.
Addition to the above query:
If I continued to take the quetiapine, would the allergic response stay the same or woufl it get worse?
Customer: replied 1 year ago.
Or will it be OK to take the quetiapine without exposure to further alcohol?
Customer: replied 1 year ago.
Could also be referred under mental health

Hi Peter. What part of your face swells? Is there any rash or redness when this occurs? How long does it typically last?

Customer: replied 1 year ago.
Around the eyes, by the nose and around the mouth. About 12 hrs

This sounds like angioedema, a leaking of fluid under the skin usually as part of an allergic reaction. How long have you been on the quetiapine? Did this ever happen to you before when you drank alcohol?

Customer: replied 1 year ago.
This time round about a week, but in 2012 for several weeks. Not with quetiapine, but with mirtazepine in 2009

I see. But the swelling does not occur unless you also drink alcohol, is this correct? What did you do about this back in 2009?

Customer: replied 1 year ago.
With the mirtazepine, I stopped using it. Have not drunk with quetiapine before, even in such small amounts.

Do you use the quetiapine just for sleep, or are there other reasons?

Customer: replied 1 year ago.
No, just for sleep - 25mg - sedative and anxiolytic (I believe). I also take dosulepine 75mg fro anxiety depression.

There are a couple approaches you could consider. One, the easiest, would be to avoid alcohol when you are taking the quetiapine. If this is not possible, you could pre-medicate with benedryl 25-50 mg one half hour prior to drinking. Because benedryl and alcohol are both sedating, you might not even need to take the quetiapine to get some sleep.

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Customer: replied 1 year ago.
I wasn't going to take any alcohol with any further doses of quetiapine. The current swelling is bad enough. My main concern was that even with the benadryl, the allergy and the potentially anaphylactic swelling would get worse? .
Customer: replied 1 year ago.
The advice that I have seen elsewhere is to stop taking the quetiapine, period - not good news.
Customer: replied 1 year ago.
Just wondered if you had other advice.

Anaphylaxis is unlikely given the predictable response so far. However, avoiding allergens that promote swelling makes sense in general. Before you stop the quetiapine, ask your doctor for an exam and basic blood tests to rule out other possible causes (e.g. low thyroid, renal issues, sinus issues, pituitary problems, etc).