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Hi Peter. What part of your face swells? Is there any rash or redness when this occurs? How long does it typically last?
This sounds like angioedema, a leaking of fluid under the skin usually as part of an allergic reaction. How long have you been on the quetiapine? Did this ever happen to you before when you drank alcohol?
I see. But the swelling does not occur unless you also drink alcohol, is this correct? What did you do about this back in 2009?
Do you use the quetiapine just for sleep, or are there other reasons?
There are a couple approaches you could consider. One, the easiest, would be to avoid alcohol when you are taking the quetiapine. If this is not possible, you could pre-medicate with benedryl 25-50 mg one half hour prior to drinking. Because benedryl and alcohol are both sedating, you might not even need to take the quetiapine to get some sleep.
Anaphylaxis is unlikely given the predictable response so far. However, avoiding allergens that promote swelling makes sense in general. Before you stop the quetiapine, ask your doctor for an exam and basic blood tests to rule out other possible causes (e.g. low thyroid, renal issues, sinus issues, pituitary problems, etc).