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Hi, this is Dr Ansari, welcome to JA
Restless legs syndrome (RLS) is a chronic condition characterized by odd sensations in the body, most commonly in the legs and an irresistible urge to move them. More than half of the patients with RLS have a family history. Most of the RLS cases are women and most of the families show characteristics of an autosomal dominant pedigree.
The most important factors in pathophysiology include low serum iron and dopaminergic system disorder.
Please go for an iron workup with your doctor, ferritin levels below 50 mic-g /lit without anemia can get benefit from iron supplements.
Familial RLS can be grouped into two subgroups. In the sporadic group, only one person in the family is affected, while in the familial (idiopathic) group, more than one person in the family is affected.
Medications that may help and can be prescribed by a Neurologist after workup can be
I personally avoid Opioids. Narcotic medications
Have you used Clonazepam with Pramipexole? in various doses.
A Task Force was established by the International Restless Legs Syndrome Study Group (IRLSSG) to develop evidence-based and consensus-based recommendations for the long-term pharmacologic treatment of restless legs syndrome/Willis-Ekbom disease (RLS/WED).
The Task Force developed guidelines based on their review of 61 papers meeting inclusion criteria, and using a modified evidence-grading scheme.
I hope this effort can be discussed with your doctor for a better outcome.