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Ask Dr. Michael Salkin Your Own Question
Dr. Michael Salkin
Dr. Michael Salkin, Veterinarian
Category: Vet
Satisfied Customers: 33293
Experience:  University of California at Davis graduate veterinarian with 45 years of experience.
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I have misread my dog's metrobactin 250mg dose. I have given

Customer Question

Hi. I have misread my dog's metrobactin 250mg dose. I have given him 6 tablets in 27 hours, instead of 3. Should I be concerned/ do anything? He seems fine, no vomiting etc, but has only ingested the last 2 about 15 minutes ago.
Submitted: 1 year ago.
Category: Vet
Customer: replied 1 year ago.
Posted by JustAnswer at customer's request) Hello. I would like to request the following Expert Service(s) from you: Live Phone Call. Let me know if you need more information, or send me the service offer(s) so we can proceed.
Expert:  Dr. Michael Salkin replied 1 year ago.

How much does Sasha weight, please? Metronidazole (Metrobactin) can be dosed in a wide range of 15-50 mg/kg although most recommend not exceeding 15 mg/kg twice daily. I regret that my state board of veterinary examiners doesn't allow me to speak to customers by phone in this venue but other experts in this category may be able to assist you in this regard. Please let me know if you'd like another expert to do so and I'll opt out of this conversation. Please stay in the conversation if you wish.

Customer: replied 1 year ago.
He probably weighs a little over 19 kilograms now. The packet says 250mg - so isn't the recommended does way over what you are saying, let alone what I've given him?!?
Customer: replied 1 year ago.
Bad maths - 285 x twice a day for his weight I think you are saying?! He has had 1710 in 27 hours, instead of 855
Expert:  Dr. Michael Salkin replied 1 year ago.

I ordinarily would dose Sasha at 15 mg/kg twice daily or ~300 mg twice daily. 1500 mg (6 x 250 mg tablets)/19 kg in a 24 (27 actually) hour period is ~79 mg/kg and that can cause symptoms of acute overdose such as anorexia, vomiting, depression, mydriasis (wide open pupils), nystagmus (eyes flicking back and forth), ataxia ("drunken sailor"), head-tilt, deficits of proprioception (not knowing where one's limbs are in space), joint knuckling, disorientation, tremors, seizures, slow heart rate, rigidity, and stiffness. These dogs usually improve within 1-2 days once the drug has been discontinued...and it should be in Sasha for at least a couple of days. Please continue our conversation if you wish.