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What type of gecko do you have?
I am sorry to hear she is having problems. Tail rot can definitely affect geckos and causes the tip of the tail to die off and become necrotic. Sometimes the tail tip has to be amputated to prevent further spread. It is also possible it is related to trauma or injury (for example bashing the tail, or a bite). I would advise gently cleaning the tail tip with dilute iodine (betadine) but be careful not to hold the tail too tight. I would also recommend bathing her daily in reptoboost to ensure she stays hydrated. This must be rinsed off the skin after use or can cause bacterial infections to worsen. It is important to book an appointment with your vet as she likely will require antibiotics and pain killers to be prescribed and may require surgery.