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Without further information it is very difficult for me to provide the best advice.
Please reply when you can and we can continue the conversation.
Panting and restlessness can have several causes including a source of pain, anxiety, canine dementia or nausea.
Given his age and breed I would want to rule out e.g. Intervertebral Disc Disease, arthritis, an anal gland impaction or dental disease.
A full vet check is best and they may wish to run some tests such as a blood test.
Hopefully we can get things sorted soon as I appreciate this must be a big worry.
All the best,
Thank you for keeping me in the loop.
It would be worth videoing the behaviour in case it may be seizure activity but I agree it may be anxiety/stress or pain related. Sometimes the distraction of the day helps with mild to moderate pain and then dogs feel it more at night.
It would be useful to do a pain relief trial as you are tonight.
I would see what the blood tests say and then we would consider further tests e.g. an MRI.