Hi there, you are through to Dr. Jake, Im a UK based vet. im sorry to hear of your concerns with your chameleon, Storm.
a chameleon of her age should be eating daily, we occasionally see lack of appetite related to shedding but this should only be transient for a 24 our period until the majority of their shed has been removed by them eating it or them rubbing it on decoration within the enclosure.
Inappetence in reptiles can be caused by a wide variety of reasons, husbandry reasons are common, its good to know that her set up is adequate though it would be a good idea to double check basking temps are correct, UV bulbs arent out of date ( generally last for 6 months), humidity is correct and that supplements arent out of date also.
female chameleons if well fed can often become reproductively active at a young age, as early as 6 months old, this causes the body to start producing egg follicles within the abdomen. this can often lead to follicular stasis where the egg development halts, one of the common signs seen in female chameleons related to this condition is lack of eating.
if she doesnt eat over the weekend i would recommend making an appointment with a local vet who has experience with reptiles, they may wish to do imaging ( x rays or ultrasound) to check she hasnt been producing follicles which have led to the inappetence. If this is the case, surgery may be required to remove the follicles, if this is clear they may recommend a blood test to check all the organs are functioning correctly and a faecal sample to check no parasites are within the gastrointestinal tract.
i would recommend increasing the humidity for the next 48 hours to aid the shedding process, if livefood is gut loaded with nutrient rich food such as salad and fruit and dusted with supplements then she should be getting enough calcium along side a UV bulb which will aid calcium absorption and vitamin d3 production. i always recommend female chameleons to have a large 6 inch deep tub available to lay eggs if they are reproductively active- they are able yo lay eggs even without a male chameleon around.
i hope all this information helps